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November 2: Garoppolo will be sidelined indefinitely because of his high ankle sprain, ESPN’s Adam Schefter reports. Jimmy G will get multiple opinions before deciding whether to undergo season-ending surgery or hold off until the end of the year. Nick Mullens, who filled in for Garoppolo on Sunday, will start in his place.

Kittle will miss “extended time,” according to Ian Rapoport of The expectation is that the tight end will be out eight weeks and it’s not certain that he’ll come back at all this season. Jordan Reed is set to return from IR and he’ll step into the starting tight end spot; fellow tight end Rose Dwelley also looms as a contributor.

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November 1: It is not a good day for the 49ers’ offense in Seattle. 49ers superstar tight end George Kittle limped to the locker room with a foot injury, according to Matt Barrows of the Athletic. Kittle caught a 25-yard pass from backup quarterback Nick Mullens when the injury occurred. The Pro Bowl tight end had two catches for 39 yards. On the season, Kittle has 37 receptions, 474 yards, and two touchdowns.

49ers quarterback Jimmy Garoppolo left in the third quarter with an ankle injury, according to Josh Alper of Pro Football Talk. The 28-year-old quarterback is no stranger to injury after he deal with a high ankle sprain earlier this season.

Backup quarterback Nick Mullens is in for the rest of the game

Garoppolo was 11 for 16, 84 yards and an interception before the injury.

Running back Tevin Coleman injured his knee during the first drive of the game. Coleman has just returned after spending six weeks on the sideline with a knee injury. He had six carries for 20 yards before exiting.

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