Los Angeles Rams running back Darrell Henderson. -- (AP Photo/Chris Szagola)

Week 2 of the 2020 NFL season was not good on the field or in fantasy football. This weekend, we saw many star players suffer major injuries that will either keep them out for a significant amount of time.

New York Giants running back Saquon Barkley is one of those players who suffered a season-ending knee injury on Sunday against Chicago. Barkley is the Giants’ best player on offense and was a top-three pick in many fantasy football drafts.

Then to make matters worse, Carolina Panthers running back Christian McCaffrey was bitten by the injury bug on Sunday. Thankfully, he will only be out 4-6 weeks, but it is still a big hit to the Panthers’ offense.

With that being said, many fantasy owners are scrambling to find the next best option on the waiver wire. Here at Pro Football Action, we are going to highlight a couple of running backs and a few other players that should be available in your respective leagues.

Darrell Henderson

If you drafted either Barkley or McCaffrey, you should be putting a waiver claim in for Los Angeles Rams running back Darrell Henderson.

The second-year running back replaced an injured Cam Akers on Sunday and put together an outstanding performance against the Philadelphia Eagles’ defense. The 5’8″ Henderson had 81 yards (career-high) on 12 carries and a touchdown. He also had two receptions for 40 yards.

The 23-year-old Henderson put up 18.1 fantasy points (FantasyPros) and showed flashes of what made him one of the top running backs at the University of Memphis.

As of right now, Henderson is available in 62 percent of fantasy leagues, which is a little bit surprising. If he can put up another solid outing against in Week 3, he could take the RB1 spot in L.A.

Mo Alie-Cox

The Indianapolis Colts have been hit hard by the injury bug over the first two weeks of the season. In Week 1, they lost running back Marlon Mack to a season-ending injury. Then on Sunday, second-year wideout Parris Campbell suffered a PCL sprain.

Losing Mack was tough, but adding the injury of Campbell hurts a lot because he led the team in targets in Week 1. However, quarterback Philip Rivers might’ve found a new weapon in former VCU basketball standout Mo Alie-Cox.

The 6’5″ tight end had a breakout game against the Vikings, recording five receptions (six targets) for 111 yards. He also played 49-percent of offensive snaps.

In terms of fantasy, Alie-Cox shattered his Week 2 projection (3.5), scoring 11.1 fantasy points (FantasyPros). He is also available in 99 percent of fantasy leagues.

Next week, the Colts are scheduled to play a struggling Jets’ pass defense that gave up 64 receiving yards to Dawson Knox (BUF) and 50 yards and two touchdowns to Jordan Reed (SF).

Jerick McKinnon

The San Francisco 49ers are banged up on both sides of the ball through two weeks. On the defensive side, they are without defensive end Nick Bosa, who is done for the season with a torn ACL.

Then, on the offensive side of the ball, quarterback Jimmy Garoppolo is hurt, along with Raheem Mostert and Tevin Coleman. Not having Mostert, who can break a game open with his speed, is a big hit to the Niners’ running game.

But then you add in the loss of Coleman, and now the ground attack looks suspicious. However, head coach Kyle Shanahan still has Jerick McKinnon and Jeff Wilson Jr. in his arsenal.

Both running backs are not game-breakers like Mostert, but they can be a factor in the passing and ground games. When it comes to McKinnon, he already has a rushing and receiving touchdown this season.

The Niners’ next opponent is the Giants, who are giving up 138 rushing yards per game on defense. McKinnon might not reach 100 rushing yards on Sunday. But could he give you 100 total yards, which is perfect for PPR play.

As of right now, he is available in over 79 percent of fantasy leagues (Fantasy Pros).

Other names to consider are Gardner Minshew II (JAX), Van Jefferson (LAR), Dalton Schultz (DAL), Chase Claypool (PIT), Isaiah Ford (MIA), Marquez Valdes-Scantling (GB), Laviska Shenault Jr. (JAX).

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