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The 49ers grabbed their first win on Sunday but also lost crucial playmakers.

49ers running back Raheem Mostert started off Sunday with an 80-yard touchdown and ended up on the injury report. He is out for 2-4 weeks with a Grade 2 MCL sprain (via PFF’s Mario Pilato).

Running back Tevin Coleman also injured his knee. Coleman rushed it 14 times for 12 yards.

The 49ers will now depend on Jerick Mckinnon and Jeff Wilson, Jr. in the backfield

McKinnon had three carries for 77 yards and a touchdown on Sunday. Wilson had four rushing touchdowns in 2019.

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  • The 49ers and free-agent defensive end Ziggy Ansah are meeting in West Virginia (via Cam Inman of the San Jose Mercury News). This will be the third time that Ansah and the 49ers are negotiating a deal after they failed to an agreement during training camp. The seven-year veteran has 50 and a half sacks in 91 games. If signed, it will also be a mini-reunion for Ansah and his defensive line coach Kris Kocurek who worked in Seattle previously.
  • Defensive end Nick Bosa “most likely” tore his ACL, according to head coach Kyle Shanahan. Bosa will have an MRI on Monday. Bosa is coming off a terrific rookie season with nine sacks and 16 tackles for loss. Defensive tackle Solomon Thomas was also carted off Sunday with a “significant” knee injury (via Adam Schefter), further testing will happen on Monday.
  • Quarterback Jimmy Garoppolo is dealing with a high-ankle sprain and could be out for 4-6 weeks. Before leaving at halftime, Garoppolo was 14-for-16, threw for 131 yards and two touchdowns. Nick Mullens came in and finished 8-for-11, 71 yds, and an interception.

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